Landsness Lab

Stroke occurs due to a loss of blood flow to the brain, resulting in significant brain injury and disability. Currently, over 7 million people in the United States suffer from the long-term effects of stroke and is the third leading cause of death in the United States. Recovery from stroke requires plasticity to allow remapping, or “rewiring,” of disrupted neuronal circuits. Such mechanisms are influenced by sleep, which is an ideal target for therapeutic intervention due to its well-studied role in mediating plasticity. Our lab studies the connection between plasticity-dependent mechanisms for stroke recovery and sleep-dependent plasticity. Our goal is to develop new, innovative sleep-focused treatments and interventions to improve outcomes in patients with neurological disease.

Principal investigator

Eric Landsness, MD, PhD

Assistant Professor of Neurology, Sleep Medicine

Eric Landsness is assistant professor of neurology and sleep medicine.  He received his undergraduate degree at the University of Washington in Electrical Engineering and his MD and PhD degree from the University of Wisconsin School of Medicine and Public Health.  Following medical school, Landsness completed his neurology residency and sleep fellowship at Washington University.  He then joined the Department of Neurology in 2017.

  Landsness lab

 

Top areas of care: sleep apnea, hypersomnia, stroke

Recent publications

• Manual assessment of cylinder rearing behavior is more sensitive than automated gait evaluations in young, male mice post-stroke of the forepaw somatosensory cortex
  July 1, 2025
  Manual assessment of cylinder rearing behavior is more sensitive than automated gait evaluations in young, male mice post-stroke of the forepaw somatosensory cortexLi, C. X., Kapoor, E., Chen, W., Ward, L. M., Lee, D. D., Titus, A., Reardon, K. M., Lee, J. M., Yuede, C. M. & Landsness, E. C., Jul 2025, In: Journal of Stroke and Cerebrovascular Diseases. 34, 7, 108325.Research output: Contribution to journal › Article › peer-review
• Region-specific non-rapid eye movement delta activity is associated with stroke recovery
  June 1, 2025
  Region-specific non-rapid eye movement delta activity is associated with stroke recoveryLandsness, E. C., Miao, H., Chen, W., Bowen, R. M., Blackwood, S. L., Tang, M. J., Lee, D. D., Padawer-Curry, J. A., Wang, X., Park, K., Hua, R. X., Schoch, K. M., Culver, J. C., Bauer, A. & Lee, J.-M., Jun 1 2025, In: Sleep. 48, 6, zsaf076.Research output: Contribution to journal › Article › peer-review
• Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy
  January 1, 2025
  Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathyParhizkar, S., Bao, X., Chen, W., Rensing, N., Chen, Y., Kipnis, M., Song, S., Gent, G., Tycksen, E., Manis, M., Lee, C., Serrano, J. R., Bosch, M. E., Franke, E., Yuede, C. M., Landsness, E. C., Wong, M. & Holtzman, D. M., 2025, (Accepted/In press) In: Nature neuroscience.Research output: Contribution to journal › Article › peer-review
• Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data
  November 1, 2024
  Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging dataZhang, X., Landsness, E. C., Miao, H., Chen, W., Tang, M. J., Brier, L. M., Culver, J. P., Lee, J. M. & Anastasio, M. A., Nov 2024, In: Journal of Neuroscience Methods. 411, 110250.Research output: Contribution to journal › Article › peer-review
• Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults
  June 1, 2024
  Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adultsSmith, S. K., Kafashan, M. M., Rios, R. L., Brown, E. N., Landsness, E. C., Guay, C. S. & Palanca, B. J. A., Jun 2024, In: BJA Open. 10, 100276.Research output: Contribution to journal › Article › peer-review
• Response to Hypoglossal Nerve Stimulation Changes with Body Mass Index and Supine Sleep
  May 9, 2024
  Response to Hypoglossal Nerve Stimulation Changes with Body Mass Index and Supine SleepPatel, R. M., Wang, H. Z., Jamro, E. L., Lindburg, M. R., Jackson, R. S., Malhotra, R. K., Lucey, B. P. & Landsness, E. C., May 9 2024, In: JAMA Otolaryngology – Head and Neck Surgery. 150, 5, p. 421-428 8 p.Research output: Contribution to journal › Article › peer-review
• Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice
  January 1, 2023
  Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in miceParhizkar, S., Gent, G., Chen, Y., Rensing, N., Gratuze, M., Strout, G., Sviben, S., Tycksen, E., Zhang, Q., Gilmore, P. E., Sprung, R., Malone, J., Chen, W., Serrano, J. R., Bao, X., Lee, C., Wang, C., Landsness, E., Fitzpatrick, J. & Wong, M. & 4 others, Townsend, R., Colonna, M., Schmidt, R. E. & Holtzman, D. M., 2023, In: Science translational medicine. 15, 693, eade6285.Research output: Contribution to journal › Article › peer-review
• Attention-Based CNN-BiLSTM for Sleep State Classification of Spatiotemporal Wide-Field Calcium Imaging Data
  January 1, 2023
  Attention-Based CNN-BiLSTM for Sleep State Classification of Spatiotemporal Wide-Field Calcium Imaging DataZhang, X., Landsness, E. C., Culver, J. P., Lee, J.-M. & Anastasio, M. A., 2023, Neural Imaging and Sensing 2023. Luo, Q., Ding, J. & Fu, L. (eds.). SPIE, 123650B. (Progress in Biomedical Optics and Imaging – Proceedings of SPIE; vol. 12365).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
• Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity
  August 15, 2022
  Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivityAlbertson, A. J., Landsness, E. C., Tang, M. J., Yan, P., Miao, H., Rosenthal, Z. P., Kim, B., Culver, J. C., Bauer, A. Q. & Lee, J. M., Aug 15 2022, In: NeuroImage. 257, 119287.Research output: Contribution to journal › Article › peer-review
• A Multivariate Functional Connectivity Approach to Mapping Brain Networks and Imputing Neural Activity in Mice
  April 15, 2022
  A Multivariate Functional Connectivity Approach to Mapping Brain Networks and Imputing Neural Activity in MiceBrier, L. M., Zhang, X., Bice, A. R., Gaines, S. H., Landsness, E. C., Lee, J. M., Anastasio, M. A. & Culver, J. P., Apr 15 2022, In: Cerebral Cortex. 32, 8, p. 1593-1607 15 p.Research output: Contribution to journal › Article › peer-review